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Total result(s) found: 16
  • An integrative analysis reveals coordinated reprogramming of the epigenome in human skeletal muscle after training
    M.E. Lindholm, F. Marabita, D. Gomez-Cabrero, H. Rundqvist, T.J. Ekström, J. Tegnér, C.J. Sundberg
    Epigenetics, 9(12):1557-69, 2014
Keywords:
450k arrays; DNA methylation; Environment; Epigenomics; Exercise; Integrative analysis; Lifestyle; Transcriptional network
  • Accelerating translational research by clinically driven development of an informatics platform – a case study
    A. Imad, S. Saevarsdottir, G. Tsipras, S. Lindblad, C. Sandin, P. Nikamo, M. Ståhle, V. Malmström, L. Klareskog, and J. Tegnér
    PLoS One, V. 9, I. 9, Article number e104382, 2014
Keywords:
Arthritis, Rheumatoid; Autoantibodies; Biological Markers; Decision Support Systems, Gene Frequency; Polymorphism, Single Nucleotide
  • Data integration in the era of omics: current and future challenges
    D. Gomez-Cabrero, I. Abugessaisa, D. Maier, A. Teschendorff, M. Merkenschlager, A. Gisel, E. Ballestar, E. Bongcam-Rudloff, A. Conesa and J. Tegnér
    BMC Systems Biology, Vol. 8 (Supp 2):I1), 2014
Keywords:
Biological Science; Computational Biology; Data Collection; Data integration
  • Biomedical research in a Digital Health Framework
    I. Cano, M. Lluch-Ariet, D. Gomez-Cabrero, D. Maier, S. Kalko, M. Cascante, J. Tegnér, F. Miralles, D. Herrera, J. Roca
    J. Transl. Med. 12(Suppl 2): S10, 2014
Keywords:
Decision Support Systems, Program Development; Pulmonary Disease, Chronic Obstructive
  • ​Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management
    J. Roca, C. Vargas, I. Cano, V. Selivanov, E. Barreiro, (...), J. Tegnér, J. Escarrabill, A. Agustí, D. Gomez-Cabrero
    Journal of Translational Medicine, 12(Suppl 2):S3, 2014
Keywords:
Cluster Analysis; Gene Expression Profiling; Lung Diseases; Lung Injury; Oxygen Consumption; Pulmonary Disease
  • Systems Medicine: from molecular features and models to the clinic in COPD
    D. Gomez-Cabrero, I. Cano, I. Abugessaisa, M. Huertas-Migueláñez, (...), J. Tegnér
    Journal of Translational Medicine, 12(Suppl 2):S4, 2014
Keywords:
Biomarkers; Comorbidity; Computer Simulation; Decision Support Systems, Energy Metabolism; Reactive Oxygen Species; Translational Medical Research
  • Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project
    F. Miralles, D. Gomez-Cabrero, M. Lluch-Ariet, J. Tegnér, M. Cascante, J. Roca
    Journal of Translational Medicine, 12(Suppl 2):S12, 2014
Keywords:
Chronic disease; Cluster analysis; Lung diseases; Pulmonary medicine; Risk assessment; Translational medical research
  • ​Synergy-COPD: a systems approach for understanding and managing chronic diseases
    D. Gomez-Cabrero, Magi Lluch-Ariet, J. Tegnér, M. Cascante, F. Miralles, J. Roca
    Journal of Translational Medicine, 12(Suppl 2):S2, 2014
Keywords:
Computer Simulation; Decision Support Systems; Delivery of Health Care; Electronic Health Records; Program Development
  • Oxygen pathway modeling estimates high reactive oxygen species production above the highest permanent human habitation
    I. Cano, V. Selivanov, D. Gomez-Cabrero, J. Tegnér, J. Roca, P.D. Wagner, M. Cascante
    PLoS One, Volume 9, Issue 11, Article number 111068, 2014
Keywords:
Altitude; Computer Simulation; Mitochondria, Models, Oxidative Stress; Oxygen
  • ​Methylome characterization of CD4+ T cells in multiple sclerosis — Establishing a role for miR-21 in autoimmune disease
    S. Ruhrmann, E. Piket, P. Bergman, L. Kular, J. Cesar, C. Lorenzi, S. Aeinehband, R. Parsa, D. Gomez-Cabrero, J. Tegnér, F. Piehl, M. Jagodic
    Journal of Neuroimmunology, Volume 275, Issues 1-2, Page 112, 2014
Keywords:
T cells; Multiple sclerosis; Autoimmune disease
  • Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis
    O. Snir, D. Gomez-Cabrero, A. Montes, E. Perez-Pampin, (...), J. Tegnér, A. Gonzalez, V. Malmström, L. Padyukov
    Arthritis Research & Therapy, 16:414, 2014
Keywords:
Autoantigens; Cyclin-Dependent Kinase 6; Enzyme-Linked Immunosorbent Assay; Genetic Predisposition to Disease; Genotype; HLA-DRB1 Chains
  • On the Theory and Algorithm for rigorous discretization in applications of Information Theory
    V. Kannan, J. Tegnér
    arXiv:1406.5104, 2014
Keywords:
Information Theory; Algorithmic probability
  • Molecular foundations of computational biomedicine
    
J. Tegnér, I. Abugessaisa, D. Gomez-Cabrero
    Chapter in Computational biomedicine, 6-32, 201
Keywords:
Computational bioscience; Nucleic acid; Protein; Computational modeling
  • ​Breast cancer MicroRNAs: clinical biomarkers for the diagnosis and treatment strategies
    G. Shafi, T.N. Hasan ,N.A. Syed , A. Paine, J. Tegnér, and A. Munshi
    Chapter in Omics Approaches in Breast Cancer, pp 171-182, Springer, 2014
Keywords:
Breast cancer; Breast cancer staging; Diagnosis; MicroRNA; Prognosis; Treatment strategies
  • ​Network biology empowering detection and understanding of interactions between genetic factors in development of complex phenotypes
    J. Tegnér, F. Marabita, D. Gomez-Cabrero
    Chapter in Between the Lines of Genetic Code, 175-194, 2014
Keywords:
Big Data; Computing; Genetic interactions; Network biology; Prediction; Systems biology
  • ​STATegra EMS: an Experiment Management System for complex next-generation omics experiments
    R. Hernández-de-Diego, N. Boix-Chova, D. Gómez-Cabrero, J. Tegnér, I. Abugessaisa and A. Conesa
    BMC Systems Biology 8(Suppl 2):S9, 2014
Keywords:
Metabolomics; Proteomics; High throughput sequencing; Human; Metabolomics