Analysis of DNA methylation in post-mortem brains from Multiple Sclerosis patients – published in Clinical Epigenetics

​Multiple sclerosis (MS), a leading cause of neurological disability in young adults, is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) characterized by autoimmune destruction of myelin and subsequent neuronal death. In this study we found that neurons of MS patients acquire sustained hypo-5mC and hyper-5hmC, which may impair CREB-mediated neuro-axonal integrity, in turn relating to their clinical symptoms.

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