01 May, 2019
Multiple sclerosis (MS), a leading cause of neurological disability in young adults, is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) characterized by autoimmune destruction of myelin and subsequent neuronal death. In this study we found that neurons of MS patients acquire sustained hypo-5mC and hyper-5hmC, which may impair CREB-mediated neuro-axonal integrity, in turn relating to their clinical symptoms.
"KAUST shall be a beacon for peace, hope and reconciliation, and shall serve the people of the Kingdom and the world."
King Abdullah bin Abdulaziz Al Saud, 1924 – 2015
Thuwal 23955-6900, Kingdom of Saudi Arabia