Integrative approaches to computational biomedicine

Authors: P.V. Coveney, V. Diaz-Zuccarini, N. Graf, P. Hunter, P. Kohl, J. Tegner, M. Viceconti
Computational biomedicine To human health Virtual physiological human

An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation 450 BeadChip platform

Authors: F. Marabita, M. Almgren, M.E. Lindholm, S. Ruhrmann, F. Fagerström-Billai, M. Jagodic, C.J. Sundberg, T.J. Ekström, A.E. Teschendorff, J. Tegnér, D. Gomez-Cabrero
DNA methylation Illumina 450K Microarray Normalization Technical variability

Implementation of the CDC translational informatics platform - from genetic variants to the national Swedish Rheumatology Quality Register

Authors: I. Abugessaisa, D. Gomez-Cabrero, O. Snir, S. Lindblad, L. Klareskog, V. Malmström, J. Tegnér
Patient de-identification Secondary use of clinical data Swedish Rheumatology Quality Register (SRQ)

Pediatric systems medicine: evaluating needs and opportunities using congenital heart block as a case study

Authors: J. Tegnér, I. Abugessaisa
Computational Biology Genomics Heart Block Newborn Pediatrics Risk Factors

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinum 450k DNA methylation data

Authors: A.E. Teschendorff, F. Marabita, M. Lechner, T. Bartlett, J. Tegnér, D. Gomez-Cabrero, S. Beck
Algorithms DNA methylation Neoplasms Normal distribution Nucleic acid probes Oligonucleotide array sequence analysis

Identification of novel markers in rheumatiod arthritis through integrated analysis of DNA methylation and microRNA expression

Authors: L. de la Rica, J.M. Urquiza, D. Gómez-Cabrero, A.B. Islam, N. López-Bigas, J. Tegnér, R.E. Toes, E. Ballestar
Rheumatoid arthritis Rheumatoid arthritis synovial fibroblasts DNA methylation Epigenetic MicroRNAs

Algorithmic complexity of motifs clusters superfamilies of networks

Authors: H. Zenil, N.A. Kiani, J. Tegnér
Algorithmic probability Complex networks Information content Information theory Kolmogorov complexity Network motifs Network typology

Importance of mitochondrial PO2 in maximal O2 transport and utilization: A theoretical analysis

Authors: I. Cano, M. Mickael, D. Gomez-Cabrero, J. Tegnér, J. Roca, P.D. Wagner
Bioenergetics Mitochondrial PO2 Mitochondrial respiration Oxygen transport V̇O2max

Testing biological models for non-linear sensitivity with a programmability test

Authors: H. Zenil, G. Ball, J. Tegnér
Biological models Non-linear sensitivity Programmability test

A vision and strategy for the virtual physiological human: 2012 update

Authors: P. Hunter, T. Chapman, P.V. Coveney, B. De Bono, V. Diaz, J. Fenner, A.F. Frangi, P. Harris, R. Hose, P. Kohl, P. Lawford, K. McCormack, M. Mendes, S. Omholt, A. Quarteroni, N. Shublaq, J. Skår, K. Stroetmann, J. Tegnér, M. Viceconti
Computational physiology Multiscale modelling Physiome Systems biology Virtual physiological human

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