An integrative analysis reveals coordinated reprogramming of the epigenome in human skeletal muscle after training

Authors: M.E. Lindholm, F. Marabita, D. Gomez-Cabrero, H. Rundqvist, T.J. Ekström, J. Tegnér, C.J. Sundberg
450k arrays DNA methylation Environment Epigenomics Exercise Integrative analysis Lifestyle Transcriptional network

Accelerating translational research by clinically driven development of an informatics platform – a case study

Authors: A. Imad, S. Saevarsdottir, G. Tsipras, S. Lindblad, C. Sandin, P. Nikamo, M. Ståhle, V. Malmström, L. Klareskog, J. Tegnér
Arthritis Rheumatoid Autoantibodies Biological markers Decision Support Systems Gene Frequency Polymorphism Single Nucleotide

Data integration in the era of omics: current and future challenges

Authors: D. Gomez-Cabrero, I. Abugessaisa, D. Maier, A. Teschendorff, M. Merkenschlager, A. Gisel, E. Ballestar, E. Bongcam-Rudloff, A. Conesa, J. Tegnér
Biological Science Computational Biology Data Collection Data integration

Biomedical research in a Digital Health Framework

Authors: I. Cano, M. Lluch-Ariet, D. Gomez-Cabrero, D. Maier, S. Kalko, M. Cascante, J. Tegnér, F. Miralles, D. Herrera, J. Roca
Decision Support Systems Program Development Pulmonary Disease Chronic Obstructive

Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management

Authors: J. Roca, C. Vargas, I. Cano, V. Selivanov, E. Barreiro, D. Maier, F. Falciani, P. Wagner, M. Cascante, J. Garcia-Aymerich, S. Kalko, I. Marin De Mas, J. Tegnér, J. Escarrabill, A. Agustí, D. Gomez-Cabrero
Cluster analysis Gene Expression Profiling Lung diseases Lung Injury Oxygen Consumption Pulmonary Disease

Systems Medicine: from molecular features and models to the clinic in COPD

Authors: D. Gomez-Cabrero, I. Cano, I. Abugessaisa, M. Huertas-Migueláñez, A. Tenyi, I. Marin De Mas, N. Kiani, F. Marabita, F. Falciani, K. Burrowes, D. Maier, P. Wagner, V. Selivanov, M. Cascante, J. Roca, A. Barabási, J. Tegnér
Biomarkers Comorbidity Computer simulation Decision Support Systems Energy metabolism Reactive Oxygen Species Translational medical research

Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project

Authors: F. Miralles, D. Gomez-Cabrero, M. Lluch-Ariet, J. Tegnér, M. Cascante, J. Roca
Chronic disease Cluster analysis Lung diseases Pulmonary medicine Risk assessment Translational medical research

Synergy-COPD: a systems approach for understanding and managing chronic diseases

Authors: D. Gomez-Cabrero, Magi Lluch-Ariet, J. Tegnér, M. Cascante, F. Miralles, J. Roca
Computer simulation Decision Support Systems Delivery of Health Care Electronic Health Records Program Development

Oxygen pathway modeling estimates high reactive oxygen species production above the highest permanent human habitation

Authors: I. Cano, V. Selivanov, D. Gomez-Cabrero, J. Tegnér, J. Roca, P.D. Wagner, M. Cascante
Altitude Computer simulation Mitochondria Models Oxidative Stress Oxygen

Methylome characterization of CD4+ T cells in multiple sclerosis — Establishing a role for miR-21 in autoimmune disease

Authors: S. Ruhrmann, E. Piket, P. Bergman, L. Kular, J. Cesar, C. Lorenzi, S. Aeinehband, R. Parsa, D. Gomez-Cabrero, J. Tegnér, F. Piehl, M. Jagodic
T cells Multiple sclerosis Autoimmune disease

Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis

Authors: O. Snir, D. Gomez-Cabrero, A. Montes, E. Perez-Pampin, J. Gómez-Reino, M. Seddighzadeh, K.U. Klich, L. Israelsson, B. Ding, A.I. Catrina, R. Holmdahl, L. Alfredsson, L. Klareskog, J. Tegnér, A. Gonzalez, V. Malmström, L. Padyukov
Autoantigens Cyclin-Dependent Kinase 6 Enzyme-Linked Immunosorbent Assay Genetic Predisposition to Disease Genotype HLA-DRB1 Chains

On the Theory and Algorithm for rigorous discretization in applications of Information Theory

Authors: V. Kannan, J. Tegnér
Information theory Algorithmic probability

Molecular foundations of computational biomedicine

Year:2014 ISSN:ISBN: 9780199658183
Authors: J. Tegnér, I. Abugessaisa, D. Gomez-Cabrero
Computational bioscience Nucleic acid Protein Computational modeling

Breast cancer MicroRNAs: clinical biomarkers for the diagnosis and treatment strategies

Authors: G. Shafi, T.N. Hasan, N.A. Syed, A. Paine, J. Tegnér, A. Munshi
Breast cancer Breast cancer staging Diagnosis MicroRNA Prognosis Treatment strategies

Network biology empowering detection and understanding of interactions between genetic factors in development of complex phenotypes

Authors: J. Tegnér, F. Marabita, D. Gomez-Cabrero
Big data Computing Genetic interactions Network biology Prediction Systems biology

STATegra EMS: an Experiment Management System for complex next-generation omics experiments

Authors: R. Hernández-de-Diego, N. Boix-Chova, D. Gómez-Cabrero, J. Tegnér, I. Abugessaisa, A. Conesa
Metabolomics Proteomics High throughput sequencing Human

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