Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory

by X.J. Wang, J. Tegnér, C. Constantinidis, P. Goldman-Rakic
Year:2004

Bibliography

Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory
X-J Wang, J. Tegnér, C. Constantinidis, and P. Goldman-Rakic
Proceedings of National Academy of Science 101:1368-1373, 2004

Abstract

​A conspicuous feature of cortical organization is the wide diversity of inhibitory interneurons; their differential computational functions remain unclear. Here we propose a local cortical circuit in which three major subtypes of interneurons play distinct roles. In a model designed for spatial working memory, stimulus tuning of persistent activity arises from the concerted action of widespread inhibition mediated by perisoma-targeting (parvalbumin-containing) interneurons and localized disinhibition of pyramidal cells via interneuron-targeting (calretinin-containing) interneurons. Moreover, resistance against distracting stimuli (a fundamental property of working memory) is dynamically controlled by dendrite-targeting (calbindin-containing) interneurons. The experimental observation of inverted tuning curves of monkey prefrontal neurons recorded during working memory supports a key model prediction. This work suggests a framework for understanding the division of labor and cooperation among different inhibitory cell types in a recurrent cortical circuit.

DOI: 10.1073/pnas.0305337101

Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory.pdf

Keywords

Synaptic inhibition Working memory Brain cortex Spatial memory Calcium-Binding Protein Vitamin D-Dependent
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