Frailty is traditionally defined as a specific geriatric syndrome characterized by increased vulnerability to unfavorable outcomes, such as falls, disability, hospitalization and overall mortality, which is a result of the impairment of manifold and interrelating biological pathways, ultimately leading to decreased homoeostatic reserve and lower resistance to stressor events, such as therapy or infections . Due to an increasing trend toward ageing of the population (the percentage of people aged ≥ 65 years is projected to increase by 20% in Europe by 2060), frailty will soon emerge as a serious and increasingly important global health burden.
DOI: https://doi.org/10.1515/cclm-2015-0147
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