Human regulatory T cells rapidly rewire the phosphoproteome of suppressed conventional T cells

​Regulatory T cells (Tregs) critically control key events of immunity in the pathogenesis of autoimmunity, allergy and cancer, primarily by suppression of effector T cells. We previously revealed that human Tregs rapidly suppress T cell receptor (TCR)-induced calcium, NFAT and NF-jB pathways in conventional T cells (Tcons) causing inhibi- tion of effector cytokine transcription. However, the exact molecular mechanism initiating this suppression remains unknown. Due to the short time period required to induce suppression, it is probable that Tregs alter protein modifications or loc alizations in suppressed Tcons rather than de novo induction of repressive proteins. Attempts at deciphering the phosphoproteomic change upon suppression are limited to targeting limited number of phospho-proteins so far.

Human regulatory T cells rapidly rewire the phosphoproteome of suppressed conventional T cells.pdf