Optimization in biology parameter estimation and the associated optimization problem

by G. Cedersund, O. Samuelsson, G. Ball, J. Tegnér, D. Gomez-Cabrero
Year:2016

Bibliography

Optimization in biology parameter estimation and the associated optimization problem
G. Cedersund, O. Samuelsson, G. Ball, J. Tegnér, D. Gomez-Cabrero
Book chapter in Uncertainty in Biology, Volume 17 of the series Studies in Mechanobiology, Tissue Engineering and Biomaterials pp 177-197, 2016

Abstract

​Parameter estimation—the assignment of values to the parameters in a model—is an important and time-consuming task in computational biology. Recent computational and algorithmic developments have provided novel tools to improve this estimation step. One of these improvements concerns the optimization step, where the parameter space is explored to find interesting regions. In this chapter we review the parameter estimation problem, with a special emphasis on the associated optimization methods. In relation to this, we also provide concepts and tools to help you select the appropriate methodology for a specific scenario.

DOI: 10.1007/978-3-319-21296-8_7

Optimization in biology parameter estimation.pdf

Keywords

Parameter estimation Optimization Heuristic Fitness function
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