Computational modeling under uncertainty: challenges and opportunities

Authors: D. Gomez-Cabrero, J. Tegnér, L. Geris
Computational modeling Uncertainty Challenges HPC Hypothesis generation

Neuroswarm: a methodology to explore the constraints that function imposes on simulation parameters in large-scale networks of biological neurons

Authors: D. Gomez-Cabrero, S. Ardid, M. Cano-Colino, J. Tegnér, A. Compte
Prefrontal cortex Workflow Ensemble analysis Working memory model Neuroscience Computational Biology

Modeling and model simplification to facilitate biological insights and predictions

Authors: O. Eriksson, J. Tegnér
Model simplificaton Model reduction Data integration Dynamical models Ordinary differential equations Piecewise linear Dynamical modules

Probabilistic computational causal discovery for systems biology

Authors: V. Lagani, S. Triantafillou, G. Ball, J. Tegnér, I. Tsamardinos
Causality Causal graphical models Bayesian networks Systems biology Biological networks

Systems understanding to personalized medicine - lessons and recommendations based on a multi-disciplinary and translational analysis of COPD

Authors: J. Roca, D. Gomez-Cabrero, J. Tegnér
Clinical decision support Integrated care Comorbidity Disease modeling Knowledge management

Proposals for enhanced health risk assessment and stratification in an integrated care scenario

Authors: I. Dueñas-Espín, E. Vela, S. Pauws, C. Bescos, I. Cano, M. Cleries (...) J. Tegnér, F. Velickovski, C. Westerteicher, J. Roca
Human experiment Information processing Morbidity Population model Prediction Risk assessment Scotland Stratification Telehealth

Human regulatory T cells rapidly rewire the phosphoproteome of suppressed conventional T cells

Authors: R.N. Joshi, N. Binai, F. Marabita, J. Tegnér, A. Schmidt
Regulatory T cells Phosphoproteome Conventional T cells

Integrative molecular profiling during human induced regulatory T cell (itreg) generation reveals novel regulators of Foxp3

Authors: A. Schmidt, F. Marabita, H. Johansson, J. Lehtiö, M. Eriksson, S. Éliás, D. Gomez-Cabrero, A. Rao, J. Tegnér
Molecular profiling human induced regulatory T cell (itreg)

Characterization and mechanistic dissection of the differentiation of Gm-csf+ Cd4+ T cells

Authors: S. Éliás, A. Schmidt, V. Kannan, J. Andersson, J. Tegnér
Gm-csf+ Cd4+ T cells

Topological evaluation of methods for reconstruction of genetic regulatory networks

Authors: J. Olczak, N. Kiani, H. Zenil, J. Tegnér
Evaluating measure Inference methods evaluation Network reconstruction Topological properties

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